NIH Revitalization Act of 1993

The 1993 Revitalization Act charged the National Institutes of Health with developing research methods that do not require animals, that reduce the number of animals used, and that produce less pain and distress in animals. Rapid advances in the biological sciences and in biotechnology have provided the tools to develop and validate novel testing methods. Since the majority of animal testing is required by regulatory agencies for toxicologic evaluations, the National Institute of Environmental Health Sciences (NIEHS), through the National Toxicology Program (NTP), has established an interagency group with representatives from 14 Federal agencies to support the infrastructure needed for the evaluation of new testing methods.



Since its inception, this group, known as the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM), has developed criteria for the validation and regulatory acceptance of new test methods. One of the ICCVAM's recent accomplishments has been the evaluation and acceptance of a new test to replace traditional skin hypersensitivity assays. The new method, a lymph node assay involving mice, uses fewer animals and produces information in a more timely way. It is likely that more test substitutes will be available for regulatory acceptance in the near future.

The NIH Revitalization Act of 1993 (Text)

Research Animal Protection

Overview of Existing System

U.S. GOVERNMENT

Department of Agriculture (USDA)

Animal & Plant Health Inspection Service (APHIS)

Animal Welfare Act (AWA)
AWA Regulations & Standards
APHIS Animal Care Policy Manual
APHIS Research Facility Inspection Guide

Department of Health and Human Services

Office of Laboratory Animal Welfare (OLAW)

Public Health Service Act (PHS)
PHS Policy on the Humane Care and Use of Laboratory Animals
Guide for the Care and Use of Laboratory Animals

Food and Drug Administration (FDA)

FDA Good Laboratory Practice for Nonclinical Lab Studies (full text)

Department of Defense (DoD)

Department of Veterans Affairs (VA)

Environmental Protection Agency (EPA)

National Science Foundation (NSF)

Federal Interagency Programs

U.S. Government Principles for the Utilization and Care of Vertebrate Animals Used in Testing, Research & Training
USDA-NIH-FDA Memorandum of Understanding
Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM)
National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicology Methods (NICEATM)
NIH Revitalization Act of 1993
ICCVAM Authorization Act of 2000 (PL 106-545, 42 U.S.C. 2851-3)

STATE GOVERNMENT

Overview of states laws affecting animal research facilities by type.

ACCREDITATION OF ANIMAL CARE PROGRAMS

Association for the Assessment and Accreditation of Laboratory Animal Care

PROFESSIONAL STANDARDS & CERTIFICATION PROGRAMS

American Association for Laboratory Animal Science (AALAS)

Management Certification
Technician Certification

American College of Laboratory Animal Medicine (ACLAM)

Veterinarian Specialty Board Certification

American Society of Laboratory Animal Practitioners (ASLAP)

American Veterinary Medical Association (AVMA)

Guidelines for Euthanasia

Association of Primate Veterinarians

Institute for Laboratory Animal Research of National Academies of Science

Public Responsibility in Medicine & Research

Certified Professional IACUC Administrator (CPIA)

Society for Neuroscience

Society of Toxicology

ANIMAL WELFARE POLICY STATEMENTS

SCIENTIFIC PUBLICATION REQUIREMENTS

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