The Society of Toxicology (SOT) is a professional and scholarly organization of 5,000 scientists from academic institutions, government and industry representing the great variety of scientists practicing toxicology in the U.S. and around the world. The Society is dedicated to supporting the creation of sound scientific information that reduces uncertainty in assessing risks to human health and the environment. Reducing uncertainty in risk assessment benefits everyone through improved decision-making that protects the health of people, animals and their environment. The SOT believes that animal research is necessary for the protection of humans and other organisms (see "Position Statement Regarding the Use of Animals in Toxicology"), and that the welfare of research animals is of paramount importance.

All applicants for membership in the Society must indicate that they will abide by the SOT Code of Ethics, which states that members will "observe the spirit as well as the letter of law, regulations and ethical standards with regard to the welfare of humans and animals involved in my experimental procedures." In addition, those who submit an abstract for presentation at the Society's meetings must conduct their research in accordance with the "Guiding Principles in the Use of Animals in Toxicology."

Good science requires that animals used in research are healthy and well cared for, and that pain and distress to the animals is minimized. In addition to ethical concerns, there are scientific reasons for this position. It is well known that altering an animal's state of health (e.g., inducing stress or pain) can alter the physiology of the animal and the outcome of an experiment.

Recognition of accomplishments in promoting animal welfare: The SOT annually presents two awards relative to the use of animals in research. The Enhancement of Animal Welfare Award recognizes outstanding and significant contributions made by members to the scientifically sound and responsible use of animals in research. The Award for Contributions to Public Awareness of the Importance of Animals in Toxicology Research encourages and recognizes individuals or organizations and their activities that enhance public understanding of, and appreciation for, the crucial benefits to humans, animals and the environment that result from the use of animals in toxicology research. The application deadline is in October.